Evonik is collaborating with KNAUER Wissenschaftliche Geräte GmbH, a manufacturer of scientific instruments, to improve the upscaling of lipid nanoparticle (LNP) formulations. By combining Evonik’s formulation and scale-up expertise with KNAUER’s technological know-how, customers can improve efficiency and increase speed to market, significantly cutting the initial pre-clinical development time.
As part of the company’s Nutrition & Care division, Evonik’s Health Care business is leveraging partnerships with life science and industry leaders to expand its portfolio of biosolutions, including innovations in nucleic acid-based medicines.
“Our extensive expertise in chemistry and formulation science has enabled us to capture a significant proportion of the growing market for mRNA and gene therapies. Thanks to our collaboration with KNAUER, we are now even better positioned to offer differentiation options,” said Yann d'Hervé, head of the Health Care business line at Evonik.
Nucleic acid therapeutics represent a huge and expanding proportion of the overall parental drugs market. Evonik supplies pharmaceutical companies worldwide with lipids and LNP drug product development activities. The LNP market alone is estimated to be over US$600 million (up to US$1billion) with continued growth projected over the next decade.
"Together with KNAUER, we can increase the speed with which we go from very small-scale prototypes to production-scale lead formulations, and then directly into GMP production of drug products,” said Andrea Engel, head of Growth Projects Evonik Health Care.
KNAUER is known for its high-end scientific instruments used in research and commercial applications. Recently, Evonik implemented KNAUER’s IJM NanoScaler Pro technology, which addresses the long-standing challenges in nucleic acid LNP formulations by reducing the need for labor-intensive and time-consuming experiments, thereby significantly reducing the time and material costs associated with screening for optimal LNP formulations on platforms that do not necessarily upscale when introduced into more proven IJM large scale systems.
"By working hand-in-hand with Evonik, we are confident that our areas of expertise complement each other, and that exceptional formulation and technology will lead to improved patient outcomes," said Anja Fuss, head of Purification & Customized Solutions at KNAUER.
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